The concomitant use of opioids with other medication that have an affect on the serotonergic neurotransmitter process has resulted in serotonin syndrome.
The following laboratory exams could possibly be influenced in clients who are obtaining therapy with promethazine hydrochloride.
Do not just take any benzodiazepines or medicines that can cause drowsiness or sleepiness through therapy with Promethazine Hydrochloride and Codeine Phosphate Oral Option. Check with your healthcare service provider for a list of these medicines if You aren't confident.
The following severe adverse reactions are described, or explained in greater detail, in other sections:
Promethazine: Promethazine is usually a phenothiazine by-product which differs structurally within the antipsychotic phenothiazines through the existence of the branched aspect chain and no ring substitution.
Having said that, this outcome just isn't constant and will be offset by a heightened fee of cervical dilation, which has a tendency to shorten labor. Check neonates exposed to opioids all through labor for indications of excess sedation and respiratory despair.
For preoperative medication, children call for doses of 0.five mg for each pound of system weight together having an correctly minimized dose of narcotic or barbiturate and the suitable dose of an atropine-like drug.
Promethazine HCl Oral Answer really should not be used in pediatric clients under two many years of age as a result of possible for deadly respiratory despair. Postmarketing instances of respiratory melancholy, including fatalities, are already claimed with use of promethazine in pediatric people less than 2 several years of age.
Promethazine HCl Oral Option is contraindicated in comatose states, and in people today acknowledged to become hypersensitive or to obtain had an idiosyncratic response to Promethazine or to other phenothiazines.
Anaphylactic reactions, as adjunctive therapy to epinephrine along with other standard click here measures, once the acute manifestations have already been managed.
Usual Grownup dosage is fifty mg Promethazine HCl Oral Option having an properly lowered dose of narcotic or barbiturate plus the essential volume of a belladonna alkaloid.
Promethazine shouldn't be Employed in pediatric people fewer than 2 several years of age because of the prospective for deadly respiratory depression.
In animal copy experiments, codeine administered by the oral route to Expecting rats throughout the period of organogenesis elevated resorptions and lowered fetal weights at a dose around 25 instances the utmost advised human dose (MRHD) from the presence of maternal toxicity (see Facts).
Promethazine is metabolized via the liver to various inactive metabolites which include sulfoxides of promethazine, N-demethylpromethazine and other glucuronides.